Hotspur House occupies a site on Cambridge Street between the railway viaduct and the River Medlock.  The OS map of 1844 shows that it started life as a cotton mill called the Medlock Mills.

By the time the Goad Insurance Map of 1888 was drawn, the building was listed as a Printing Works owned by the Percy Brothers Ltd.

An article on the "placenorthwest.co.uk" website dated August 20, 2015 reported that, "... MCR Property Group has exchanged contracts to purchase Hotspur House, a 19th-Century mill in Cambridge Street, Manchester, for around £2.5m.  The 56,000 sq ft five-storey warehouse was formerly used as a cotton mill, before being taken over by printing company Percy Brothers. The building was used as a printing shop until 2011.  The warehouse currently provides studio space for artists and musicians. .... The area around Hotspur House could be affected by a compulsory purchase order as part of Network Rail’s extensive works at the nearby Oxford Road Railway Station. MCR said that it was proposing to work with Network Rail on the future of the site."

The images below were taken in March of 2017 at which time the building was boarded up and apparently unoccupied.