Manchester House is located at 86 Princess Street.  This red sandstone and pink brick building has been ascribed to the architect I. R. E. Birkett and was built between 1906 and 1909.  The building fronts onto Princess Street and the River Medlock runs behind it.  Once a packing and shipping warehouse, Manchester House today is home to a diverse collection of businesses including: textile merchants and agents, solicitors, medical & dental labs, accountants and two restaurants.

During the 19th Century the River Medlock was flanked by mills of various kinds and this site, where Manchester House sits today, was once home to J. & J. M. Worrall's Ltd. Bleachers and Finishers.  Their mill ran from Charles Street to the corner where Manchester House sits today.