The A. V. Hill Building on Upper Brook Street is named after Archibald Vivian Hill.  Hill was a physiologist and biophysicist who was appointed as a professor of physiology at the University between 1920 and 1923.  It was during that time that he, along with Otto Meyerhof, was awarded the Nobel Prize for Physiology or Medicine for discoveries concerning the production of heat in muscles.

The building is home to the faculties of Life Sciences and Medicine and focuses on neuroscience and immunology.  It was designed by the architectural practice of Wilson Mason and completed in the Autumn of 2008.  The practice has offices in London and Preston and they focus on commercial, corporate and educational clients.  Among their other projects they list the Oxford Street store of John Lewis, the former ILVA store on Great Ancoats Street in Manchester, and a manufacturing facility for BAE Systems Joint Strike Fighter project.