The distinctive pyramidal tower on Dover Street surmounts the former Manchester High School for Girls.  The tower mirrors Waterhouse's University buildings and Worthington's Nicholl's Hospital.  The High School for Girls was designed in 1881 by Mills and Murgatroyd, the architects of the Royal Exchange.

Today it is known as the Dover Street Building of the University of Manchester.  It is home to the Well-Being Room and the Dover Street Building Café.