In 2011 Unison moved out of their 1970s tower block at 1 Mabledon Place across Euston Road to this new building.  In fact only part of this new headquarters is new because the site incorporates the Grade II listed Elizabeth Garrett Anderson Hospital built in the 19th century.  Designed by Squire and Partners, the new office building wraps around the old hospital and the space between the two forms a courtyard with a glass roof.

The architect's website says that, "The design maximises the potential of the existing listed buildings, as well as providing a new, efficient office space for UNISON. The HQ gained planning consent in February 2008, and completed May of 2011. Squire and Partners was also commissioned to undertake the fitout for UNISON including the provision of TV/radio studios, press rooms, conference facilities, catering facilities and a large council debating chamber. The scheme achieves over 50% carbon reductions above Part L of the Building Regulations and the biomass boiler and photovoltaics will ensure that 20% of energy is from renewable sources. Upon completion UNISON achieved a score of 73.53% and was awarded a BREEAM rating of ‘Excellent.’ Squire and Partners' scheme has improved the existing townscape and the setting of the listed buildings, with animation at ground floor and street level providing a focus for the development, and enhancing the site's presence on the Euston Road and Churchway."