In 1928 the hotel was given an extensive redevelopment in the Art Deco style and when it reopened in it boasted 980 bedrooms.  it featured a Winter Garden Restaurant that could seat 500 guests attended by a staff of over 100.   The Art Deco conversion is credited to Oliver P. Bernard and the Victoria & Albert Museum website says that his, "... designs for the Strand Palace made this one of the most celebrated hotel interiors in London. Bernard had worked as a set-designer in theatre and opera, in Britain and the USA. This experience clearly influenced his work at the Strand Palace. The foyer combined traditional and new materials and made innovative use of glass and lighting. The walls were clad with pale pink marble and the floor with limestone. The balustrades, columns and door surrounds were made of translucent moulded glass, chromed steel and mirror glass. ....  The foyer was removed from the Strand Palace Hotel in 1969 and, for the first time, was partially reconstructed for the recent Art Deco exhibition."

During WWII the hotel was popular with American forces and was apparently designated as an official US "rest and recuperation" residence.  After the war the hotel further improvements increased the number of bathroom facilities which resulted in a reduction in the number of bedrooms to 786.  The hotel's website in 2018 says that, "...  the Strand Palace Hotel would now be unrecognisable to guests from the Edwardian era. But links with the past still remain: a few Art Deco touches are visible inside and outside the building; guests from the war years still return to relive their memories. Outside, The Strand remains a buzzing focal point of West End life, just as it was in 1909."