This Category B Listed building was erected in two phases along Castle Street.  The Statement of Special Interest explains that, "... R R Anderson selected a design by H E Clifford for the hospital but the Hopsital Committee awarded the commission to Miller. In execution, it was simplified, though still has applied ornament. In 1915, the new infirmary was in the forefront of hospital design; stress had been laid upon minimising noise and upon cleanliness, while on the technological side there were sophistications such as X-ray (the infirmary had in 1896 the first Roentgen ray laboratory in the world) and an electro-cardiograph system linking each ward to a central monitoring area."

It involves a "... Large complex of hospital buildings ... Built or clad mostly in ashlar, probably Giffnock stone, with concealed or slated roofs. Glazing to ward blocks mostly 3-pane single windows, each comprising sliding sash and case in combination with top-hoppers. Courtyard buildings all steel-framed, with generous fenestration."